Dr. Xu
Winner of the 5th Youth PI Research Assistance Scholarship from Origin
Shanghai Jiao Tong University
Molecular Mechanisms of Interactions between Pathogenic Bacteria
Introduction
Dr. Xu obtained her bachelor’s degree from the College of Biological Sciences at China Agricultural University and completed her doctoral and postdoctoral training at the National Institute of Biological Sciences. She is currently a Principal Investigator at Shanghai Jiao Tong University School of Medicine.
Her research focuses on the molecular mechanisms underlying innate immune surveillance and host-pathogen interactions. Her lab aims to define PRR-PAMP/DAMP pairs, dissect key pathways involved in endomembrane damage sensing and non-canonical autophagy, and elucidate how pathogens evade host immune surveillance through unconventional enzymatic activities and unique biochemical strategies.
Selected Publications
1.Shao, Y.#, Yang, D.#, Gao, X., Wang, M., Meng, L., Niu, T., Xia, L., Ding, J., Shao, F., Xu, Y. Bacterial effector OspB hijacks apoptosis through peptide-bond recombination of BH3 domain proteins. Cell Host & Microbe (2025) 33, 1886-1900. 2.Xu, Y., Zhou, P., Cheng, S., Lu, Q., Nowak, K., Hopp, A.K., Li, L., Shi, X., Zhou, Z., Gao, W., Li, D., He, H., Liu, X., Ding, J., Hottiger, M. O., Shao, F. A bacterial effector reveals the V-ATPase-ATG16L1 axis that initiates xenophagy. Cell (2019) 178, 552-566 e520. 3.Xu, Y., Cheng, S., Zeng, H., Zhou, P., Ma, Y., Li, L., Liu, X., Shao, F.*, Ding, J.* ARF GTPases activate Salmonella effector SopF to ADP-ribosylate host V-ATPase and inhibit endomembrane damage-induced autophagy. Nature Structural & Molecular Biology (2022) 29, 67-77.
info@benyuanfoundation.org
